A pharmacokinetic investigation of the distribution and elimination of diethylpropion and its metabolites in man-Reference-Cited by-同舟云学术

A pharmacokinetic investigation of the distribution and elimination of diethylpropion and its metabolites in man

Published:1974-09 Issue:9 Volume:26 Page:711-721
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Mihailova D¹,Rosen A¹,Testa B¹,Beckett A H¹

Affiliation:

1. Department of Pharmacy, Chelsea College (University of London), Manresa Road, London SW3 6LX, UK

Abstract

Abstract Analogue and digital computing techniques have been used to elucidate the pharmacokinetic parameters involved in the metabolism and excretion of diethylpropion and its metabolites in man. Rate constants for the various processes have been evaluated for the complex reaction scheme. The values of the rate constants are used as a basis for discussion of the relative importance of some of the metabolic routes.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/26/9/711/37650773/j.2042-7158.1974.tb09355.x.pdf

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1. Use of the analogue computer to examine the quantitative relation between urinary pH and kidney reabsorption of drugs partially ionized at physiological pH

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3. Reductase for Aromatic Aldehydes and Ketones

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