Multicomponent analysis of ultraviolet spectra: application to pharmaceutical dosage forms

Author:

Madsen B W1,Robertson J S1

Affiliation:

1. Pharmacy Department, University of Sydney, Sydney, Australia

Abstract

Abstract Assay of sulphacetamide and physostigmine eye drops, sulphadi-midine and tri-sulphonamide tablets, and a triple barbiturate capsule has been possible without prior extraction or purification of the ingredients. Concentration estimates were found using the method of least squares, and safeguards were incorporated in the computer program to determine confidence levels. The method should be applicable to other agents and dosage forms and lend itself to automation.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Cited by 7 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Multicomponent spectrometric analysis of drugs and their preparations;Profiles of Drug Substances, Excipients and Related Methodology;2019

2. Sulfacetamide;Analytical Profiles of Drug Substances and Excipients;1994

3. Computer-assisted spectrophotometry: Multicomponent analysis with a discrete fourier transform;Talanta;1990-12

4. Computerized Derivative Spectrophotometric Assay of two Component Mixture Using Least Squares Method;Drug Development and Industrial Pharmacy;1990-01

5. Chemometrics in pharmaceutical analysis;Journal of Pharmaceutical and Biomedical Analysis;1987-01

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