Prostaglandins and the anti-inflammatory activity of a human plasma fraction in carrageenan-induced paw oedema in the rat-Reference-Cited by-同舟云学术

Prostaglandins and the anti-inflammatory activity of a human plasma fraction in carrageenan-induced paw oedema in the rat

Published:1974-09 Issue:9 Volume:26 Page:692-698
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Smith M J H¹,Ford-Hutchinson A W¹,Elliott P N C¹,Bolam J P¹

Affiliation:

1. Department of Biochemical Pharmacology, King’s College Hospital Medical School, Denmark Hill, London S.E.5, UK

Abstract

Abstract A fraction prepared from normal human plasma inhibits the swelling of the acute carrageenan-induced paw oedema in the rat. Treatment of the animals with prostaglandin E1, arachidonic acid or with substances which either block the formation of prostaglandins or antagonize their action showed that these mediators are concerned in the development of the paw oedema. The anti-inflammatory effect of the plasma fraction in the carrageenan reaction does not involve a specific interference with the prostaglandin system. The plasma fraction is not an inhibitor of the action of SRS-A on the guinea-pig ileum.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/26/9/692/37649393/j.2042-7158.1974.tb09352.x.pdf

Reference17 articles.

1. Selective Inhibitor of Slow Reacting Substance of Anaphylaxis

2. The Role of Prostaglandin E₁ in Inflammatory Process in the Rat

3. Observations on the pharmacological properties of inflammatory exudate

4. Histamine, 5-hydroxytryptamine, kinins and the anti-inflammatory activity of human plasma fraction in carrageenan-induced paw oedema in the rat

5. Biological properties of carrageenan

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