THE ANALGESIC ACTION OF NORMORPHINE ADMINISTERED INTRACISTERNALLY TO MICE

Author:

Lockett Mary F1,Davis M M1

Affiliation:

1. Department of Physiology and Pharmacology, Chelsea Polytechnic, London, S.W.3

Abstract

Abstract The analgesic action of normorphine developed more rapidly than that of morphine and was, weight for weight, as great as that of morphine, and was as effectively antagonised by N-allylnormorphine when these drugs were administered intracisternally to mice. By this route, more than one molecule of N-allymonnoirphine was required to antagonise the action of one molecule of analgesic drug.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Reference4 articles.

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