The assay and stability of chlorpropamide in solid dispersion with urea-Reference-Cited by-同舟云学术

The assay and stability of chlorpropamide in solid dispersion with urea

Published:1979-09 Issue:1 Volume:31 Page:726-729
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Ford James L¹,Stewart Alan F¹,Rubinstein Michael H¹

Affiliation:

1. School of Pharmacy, Liverpool Polytechnic, Byrom Street, Liverpool L3 3AF, UK

Abstract

Abstract Thin layer chromatography followed by reflectance densitometry has been used to evaluate the stability of chlorpropamide-urea during the fusion process. Urea was found to decompose to biuret and chlorpropamide to p-chlorobenzenesulphonamide: several other unidentified decomposition products were detected. The energy for decomposition of chlorpropamide was 57·1 kJmol−1 for melts containing 15 and 30% chlorpropamide. Decomposition followed apparent first order kinetics.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/31/1/726/37760445/j.2042-7158.1979.tb13645.x.pdf

Reference17 articles.

1. Ph.D. Thesis;Allen,1972

2. Iodine as a Means of Development in Paper Chromatography

Cited by 19 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Current pharmacological treatments for SARS-COV-2: A narrative review;European Journal of Pharmacology;2020-09

2. The role of the carrier in the formulation of pharmaceutical solid dispersions. Part I: crystalline and semi-crystalline carriers;Expert Opinion on Drug Delivery;2016-06-20

3. Effect of storage conditions on the recrystallization of drugs in solid dispersions with crospovidone;Pharmaceutical Development and Technology;2013-05-17

4. Amorphization of pharmaceutical compound by co-precipitation using supercritical anti-solvent (SAS) process (Part I);The Journal of Supercritical Fluids;2010-06

5. The preparation of a solid dispersion powder of indomethacin with crospovidone using a twin-screw extruder or kneader;International Journal of Pharmaceutics;2009-01-05