Affiliation:
1. Research Laboratories of Medica Ltd., P.O.B. 325, SF-00101 Helsinki 10, Finland
Abstract
Abstract
In the rat, administration of 3-(3,4-dihydroxy)-l-phenylalanine (l-dopa) simultaneously with the corresponding α-keto acid, 3,4-dihydroxyphenylpyruvic acid (DHPPA), gives significantly higher concentrations of l-dopa in the serum and of dopamine and homovanillic acid in the brain than the same dose of l-dopa alone. Correspondingly, DHPPA potentiates the effect of l-dopa on the locomotor activity in reserpine-treated mice. DHPPA is postulated to increase the absorption of intact l-dopa from the gut by preventing the transamination reaction between l-dopa and the physiological α-keto acids.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Cited by
6 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献