Affiliation:
1. Pharmacy Department, University of Manchester, Manchester, M13 9PL, UK
Abstract
Abstract
The surface activity at the air-solution interface of a series of β-adrenoceptor blocking agents has been determined. The drugs investigated included, propranolol, sotalol, oxprenolol, labetolol, timolol, metoprolol and acebutolol. Correlation between surface activity and local anaesthetic potency of the drugs is examined. Light scattering measurements have indicated self-association of sotalol, oxprenolol, acebutolol and metoprolol in 0.5 mol kg−1 sodium chloride. Critical micelle concentrations and aggregation numbers are reported.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Cited by
31 articles.
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