Acidic metabolites of Δ1-tetrahydrocannabinol isolated from rabbit urine-Reference-Cited by-同舟云学术

Acidic metabolites of Δ1-tetrahydrocannabinol isolated from rabbit urine

Published:1979-09 Issue:1 Volume:31 Page:231-237
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Nordqvist Marianne,Lindgren Jan-Erik¹,Agurell Stig¹²

Affiliation:

1. Astra Läkemedel AB, S-151 85 Södertälje, Sweden

2. Department of Pharmacognosy, Faculty of Pharmacy, BMC, Box 579, S-751 23 Uppsala, Sweden

Abstract

Abstract The in vivo metabolism of Δ1-tetrahydrocannabinol (Δ1-THC) was investigated in the rabbit after i.v. administration. Thirteen acidic metabolites were isolated from rabbit urine and identified by gas chromatography-mass spectrometry and by proton magnetic resonance spectroscopy. One additional metabolite was tentatively identified. All but three were new metabolites and all but one were oxidized in the pentyl side chain. The metabolites included dicarboxylic acids, monocarboxylic acids and mono- or dihydroxylated derivatives thereof. However, the dicarboxylic acid metabolites were the most prominent.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/31/1/231/37760093/j.2042-7158.1979.tb13485.x.pdf

Reference35 articles.

1. On the metabolism of tritium-labelled Δ1-tetrahydrocannabinol in the rabbit

2. Structural studies of cannabinoids. Theoretical and proton magnetic resonance analysis

3. Transformation of Δ1-tetrahydrocannabinol (THC) by rabbit liver microsomes

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