Affiliation:
1. Faculty of Engineering, Fukuyama University, Gakuen-cho, Fukuyama 729-02, Japan
Abstract
Abstract
Honokiol and magnolol, neolignans in Magnolia obovata, have been evaluated as antioxidants.
Microsomal lipid peroxidation induced by Fe(III)-ADP/NADPH and mitochondrial lipid peroxidation induced by Fe(III)-ADP/NADH were inhibited by these compounds. These neolignans protected mitochondrial respiratory chain enzyme activity against NADPH-induced peroxidative stress and protected red cells against oxidative haemolysis. The anti-oxidative activity of honokiol was more potent than that of magnolol.
Neolignans in M. obovata were shown to be effective in protecting biological systems and functions against oxidative stress.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Reference28 articles.
1. Microsomal lipid peroxidation;Buege,1978
2. Antimicrobial activity of phenolic constituents of Magnolia grandiflora L;Clark;J. Pharm. Sci.,1981
3. Comparison of the antioxidative activity of some acid phenols: structure-activity relationship;Cuvelier;Biosci. Biotech. Biochem.,1992
4. Biphenyl compounds are hydroxyl radical scavengers: their effective inhibition for UV-induced mutation in Salmonella typhimurium TA 102;Fujita;Environ. Mut. Res. Commun.,1994
5. Epidemiological correlations between poor plasma levels of essential antioxidants and the risk of coronary heart disease and cancer;Gay,1992
Cited by
63 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献