Characterization of the Influence of some Cyclodextrins on the Stratum Corneum from the Hairless Mouse-Reference-Cited by-同舟云学术

Characterization of the Influence of some Cyclodextrins on the Stratum Corneum from the Hairless Mouse

Published:1997-04 Issue:4 Volume:49 Page:397-402
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Bentley M Vitória L B¹,Vianna Renata F¹,Wilson Susan²,Collett John H²

Affiliation:

1. Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Av do Café s/n, 14040-903, Ribeirão Preto - SP, Brasil

2. Department of Pharmacy and of Biological Sciences, University of Manchester, Oxford Road, Manchester, M13 9PL, UK

Abstract

Abstract Differential scanning calorimetry (DSC), Fourier-transform infrared (FTIR) spectroscopy and transmission electron microscopy (TEM) have been used to determine the influence of β-cyclodextrin (β-CyD), hydroxypropyl-β-CyD (HP-β-CyD) and γ-CyD on the structural properties of the stratum corneum from the hairless mouse. Some modest changes in the stratum corneum lipid transition temperature were induced by HP-β-CyD and blue shifts were observed in the FTIR spectra of the C–H asymmetric and symmetric stretching of the lipids from the stratum corneum. Results from TEM studies indicated that HP-β-CyD caused removal and possible disorganization of the lipid matrix that envelopes the corneocytes of the stratum corneum, whereas no effect was seen after treatment of the samples with β-CyD and γ-CyD. These results suggest that HP-β-CyD can increase the permeability of the stratum corneum possibly as a result of extraction of lipids, and might thus enhance drug permeation through the skin.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/49/4/397/37019625/j.2042-7158.1997.tb06813.x.pdf

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