A Xanthanolide with Potent Antibacterial Activity against Methicillin-resistant Staphylococcus aureus

Author:

Sato Youichi12,Oketani Hideki2,Yamada Tomoko2,Singyouchi Ken-Ichi12,Ohtsubo Tetsuya12,Kihara Masaru2,Shibata Hirofumi2,Higuti Tomihiko2

Affiliation:

1. Alps Pharmaceutical Industries Co., Ltd., 10-50, 2-Chome, Mukaimachi, Furukawa, Gifu 509-42, Japan

2. Faculty of Pharmaceutical Sciences, The University of Tokushima, Shomachi 1-78, Tokushima 770

Abstract

Abstract This study was conducted to find constituents of an annual herb, Xanthium sibiricum Patr er Widd, with effective antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). By monitoring antibacterial activity against MRSA strains, it was shown that a sesquiterpene lactone, identified as [3aR-(3aα,7β,8aβ)]-3,3a,4,7,8,8a-hexahydro-7-methyl-3-methylene-6-(3-oxo-1-butenyl)-2H-cyclohepta[b]furan-2-one, or xanthatin, isolated from leaves of the herb, had outstandingly potent activity against S. aureus species, including MRSA; its activity against MRSA and MSSA strains was similar. Other bacteria, e.g. Staphylococcus epidermidis, Klebsiella pneumoniae, Bacillus cereus, Pseudomonas aeruginosa and Salmonella typhi, were also susceptible at the concentrations tested but the compound had no inhibitory effect on some other bacteria, including Escherichia coli. The results show that xanthatin has outstandingly potent activity against strains of S. aureus but that the activity of the compound is highly species-specific.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Reference13 articles.

1. Further eudesmanolides and xanthanolides from Telekia speciosa.;Bohlmann;Phytochemistry,1981

2. Methicillin-resistant Staphylococcus aureus.;Brumfitt;N. Engl. J. Med.,1989

3. Epidemiology of drug resistance: implications for a post-antimicrobial era.;Cohen;Science,1992

4. Xanthinin. II. The structure of xanthinin and xanthatin;Deuel;J. Am. Chem. Soc.,1957

5. Japanese Society for Antimicrobial Chemotherapy;Chemotherapy (Tokyo),1981

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3