Histamine gastric ulceration in the guinea-pig. Some observations on a new method

Abstract

Abstract Consistent gastric ulceration can be produced in suitable strains of guinea-pig, after high duodenal ligation under pentobarbitone anaesthesia, by the subcutaneous injection of a relatively low dose of aqueous histamine acid phosphate. The ulceration coincides with a dose of histamine which produces sub-maximal secretion volume and which is greater than that producing the maximum secretion. The method does not require antihistamine cover, and it is shown that antihistamines may complicate the true histamine response by the stomach. The results provide evidence that this type of ulceration follows the action of gastric juice on a functionally impaired mucosa.