Adjuvant effect of aluminium monostearate paraffin gels on antitoxin response

Abstract

Abstract Clostridium welchii Type D toxoid has been dispersed in aluminium monostearate-hydrocarbon gels. When these are injected subcutaneously in laboratory animals the antitoxin response is influenced by the method of preparation of the gels. The level and duration of the antitoxin titre in the blood is related directly to the viscosity of the vaccine preparations. Six months after injection, the residual antitoxin titre produced by the most successful treatments was still as good as the peak titre obtained from simple aluminium hydroxide adsorbed vaccine.