Micellar properties and surface activity of some bolaform drugs in aqueous solution

Abstract

Abstract The micellar properties of a series of dicationic drugs with structures resembling those of the bolaform electrolytes have been examined using light scattering, surface tension and conductivity techniques. The compounds investigated included, demecarium bromide, ambenonium chloride, dequalinium acetate, distigmine bromide and chlorhexidine acetate. Demecarium and dequalinium formed micelles at critical concentrations of 9 times 10−3 and 4 times 10−3 mol kg−1 respectively. No significant association of chlorhexidine acetate could be detected, contrary to previous reports.