Factors affecting the release and excretion of dopamine in the rat

Author:

Akpaffiong M J1,Redfern P H1,Woodward B1

Affiliation:

1. School of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, BA2 7 A Y, UK

Abstract

Abstract The effects of inorganic salts and of diuretic agents on the excretion of dopamine (DA) were examined in the rat. Both types of treatment evoked significant increases in urinary DA excretion, urine volume and urinary sodium excretion. In the salt-treated animals a significant correlation was observed between DA excretion and urine volume, whereas after diuretic treatment there was better correlation between DA and urinary sodium excretion. The salt- treated animals showed a high correlation between administered chloride and DA excretion. Subcutaneous administration of DA produced a significant diuresis and an increase in sodium excretion. The mechanisms responsible for these responses are discussed with reference to the possibility that DA has a physiological role in the kidney.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

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4. D1Dopamine receptor signalling defect in spontaneous hypertension;Acta Physiologica Scandinavica;2000-01

5. Renal Dopamine Receptors in Health and Hypertension;Pharmacology & Therapeutics;1998-11

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