The reflection of ejecting and retaining currents in the time-course of neuronal responses to microelectrophoretically applied drugs

Abstract

Abstract The role of ejecting and retaining currents in determining the time-course of neuronal responses to microelectrophoretically applied drugs (acetylcholine, glutamate, noradrenaline, 5-hydroxytryptamine, and mescaline) was investigated. Comparing the parameters of excitatory responses to ejecting currents of successively increasing intensity, the following changes were observed: the response latency became progressively shorter, the plateau became higher, and the recovery time was prolonged. An increase in the intensity or duration of the pre-ejection retaining current resulted in the prolongation of the response latency and the latency to plateau, but did not alter the plateau itself. An increase in the intensity of the post-ejection retaining current reduced the recovery time of the response.