A circular dichroic investigation of the binding of fenoprofen, 2(3-phenoxyphenyl)-propionic acid, to human serum albumin-Reference-Cited by-同舟云学术

A circular dichroic investigation of the binding of fenoprofen, 2(3-phenoxyphenyl)-propionic acid, to human serum albumin

Published:1973-03 Issue:3 Volume:25 Page:208-212
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Perrin J H¹

Affiliation:

1. Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, Indiana 46206, USA

Abstract

Abstract The extrinsic Cotton effects found on the binding of fenoprofen and some of its analogues to human serum albumin have been investigated. The fenoprofen appears to bind hydrophobically to the albumin via the phenyl rings and after dipole interactions of the carbonyl group and the ether oxygen. This binding is non-stereospecific.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/25/3/208/37632339/j.2042-7158.1973.tb10626.x.pdf

Reference9 articles.

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