Affiliation:
1. University of Dundee, Department of Pharmacology and Therapeutics, Dundee, DD1 4HN, UK
Abstract
Abstract
Histamine formation was measured by the [14C]histamine content of the stomach following injection of [14C]histidine into rats. Carbonyl reagents (e.g. oxyamines) which inactivate pyridoxal phosphate, the co-enzyme of histidine decarboxylase, were the most effective inhibitors of histamine formation in vivo. Although the oximes prepared from imidazol-4(5)-ylmethoxyamine and pyridoxal or pyridoxal phosphate cannot inactivate the co-enzyme, they proved sufficiently potent to merit further study as inhibitors of histamine formation in vivo.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Cited by
8 articles.
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