Gas chromatographic determination of ethosuximide and phensuximide in plasma and urine of man-Reference-Cited by-同舟云学术

Gas chromatographic determination of ethosuximide and phensuximide in plasma and urine of man

Published:1973-04 Issue:4 Volume:25 Page:324-327
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

van der Kleijn Eppo¹²,Collste Per¹²,Norlander Björn¹²,Agurell Stig¹²,Sjöqvist Folke¹²

Affiliation:

1. Sint Radboud Hospital Pharmacy, University of Nijmegen, Nijmegen, the Netherlands

2. Department of Clinical Pharmacology, University of Linköping, Linköping, Central Military Pharmacy, Karolinska Hospital, Stockholm, Sweden

Abstract

Abstract Ethosuximide and phensuximide in plasma and urine can be assayed to a concentration of 2–5 μg ml−1 by a rapid and specific gas chromatographic assay. The method can be used to monitor plasma concentrations in patients with petit mal treated with these drugs alone or in combination with other antiepileptic drugs. The steady-state plasma concentrations of ethosuximide in children given 10–45 mg kg−1 day−1 varied between 10 and 150 μg ml−1 indicating marked interindividual differences in pharmacokinetics.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/25/4/324/37659609/j.2042-7158.1973.tb10016.x.pdf

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4. A plasticizer in lipid extracts of human blood

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