The effect of free silica on the mucosal protective and antiflatulent properties of polydimethylsiloxane-Reference-Cited by-同舟云学术

The effect of free silica on the mucosal protective and antiflatulent properties of polydimethylsiloxane

Published:1973-11 Issue:11 Volume:25 Page:859-863
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Birtley R D N¹²,Burton J S²,Kellett D N¹,Oswald B J²,Pennington J C¹

Affiliation:

1. Huntingdon Research Centre, Huntingdon, PE18 6ES

2. Berk Pharmaceuticals Limited, Cattershall Lane, Godalming, Surrey, UK

Abstract

Abstract The mucosal protective and antiflatulent properties of polydimethylsiloxane (PMS) alone, or containing free silica have been examined in rats. Both PMS and PMS + 6% silica significantly protected rat gastric mucosa from the irritant effects of aspirin but there was no significant difference between the protective effect of each agent. The antiflatulent property of PMS, as determined by X-ray measurements of foam production in the rat stomach, was significantly enhanced by the addition of free silica.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/25/11/859/37632906/j.2042-7158.1973.tb09963.x.pdf

Reference9 articles.

1. An infrared study of the interaction between Aerosil-200 and polydimethylsiloxane (dimethicone-1000)

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