Locomotor activity stimulation in rats produced by dopamine in the nucleus accumbens: potentiation by caffeine-Reference-Cited by-同舟云学术

Locomotor activity stimulation in rats produced by dopamine in the nucleus accumbens: potentiation by caffeine

Published:1975-09 Issue:9 Volume:27 Page:666-670
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Andén Nils-Erik¹,Jackson David M¹

Affiliation:

1. Department of Pharmacology, University of Göteborg, Fack, S-400 33 Göteborg 33, Sweden

Abstract

Abstract The increased motor activity of reserpine-nialamide pretreated rats given dopamine into the nucleus accumbens was potentiated in a dose-dependent manner by systemically administered caffeine. Similarly, the increase in motor activity seen when the endogenous dopamine was released by intraperitoneally administered amphetamine was potentiated by systemically given caffeine. These effects might be due to an increase in the dopamine-induced accumulation of cyclic AMP in the nucleus accumbens after inhibition of the phosphodiesterase by caffeine.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/27/9/666/37624935/j.2042-7158.1975.tb09529.x.pdf

Reference15 articles.

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2. Vergleichende Untersuchungen �ber zentrale Wirkungen von Xanthinderivaten in Hinblick auf deren Stoffwechsel und Verteilung im Organismus

3. DOPAMINE IN THE MESOLIMBIC SYSTEM OF THE RAT BRAIN: ENDOGENOUS LEVELS AND THE EFFECTS OF DRUGS ON THE UPTAKE MECHANISM AND STIMULATION OF ADENYLATE CYCLASE ACTIVITY

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