Improvement of solubility and dissolution rate of poorly water-soluble salicylic acid by a spray-drying technique-Reference-Cited by-同舟云学术

Improvement of solubility and dissolution rate of poorly water-soluble salicylic acid by a spray-drying technique

Published:1975-01 Issue:1 Volume:27 Page:1-5
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Kawashima Y¹,Saito M¹,Takenaka H¹

Affiliation:

1. Gifu College of Pharmacy, Mitahora, Gifu 502, Japan

Abstract

Abstract Spray drying techniques have been applied to improve the solubility and dissolution rate of poorly water-soluble salicylic acid. Spray drying of the acid dispersed in acacia solutions resulted in as much as a 50% improvement in the solubility of the product. Solubility improvement was closely related not only to the concentration of acacia but also the amount of amorphous material in the spray-dried products. The heat of solution was inversely related to these parameters. The dissolution rate of spray-dried product was almost instantaneous being about 60 times faster than that of the original powder. A great improvement in the wettability of the spray-dried material seemed to be mainly responsible for the increase of dissolution rate.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/27/1/1/37612411/j.2042-7158.1975.tb09369.x.pdf

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2. Some parameters describing the dissolution rate of salicylic acid at controlled pH

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