Platelet activating factor and the responses of rat isolated stomach strip to prostaglandin E2-Reference-Cited by-同舟云学术

Platelet activating factor and the responses of rat isolated stomach strip to prostaglandin E2

Published:1993-08 Issue:8 Volume:45 Page:761-762
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Izzo A A¹,Mascolo N¹,Autore G¹,Capasso F¹

Affiliation:

1. Department of Experimental Pharmacology; University of Naples “Federico II”, via Domenico Montesano 49, 80131 Naples, Italy

Abstract

Abstract The effect of platelet activating factor (PAF) on contractions evoked by acetylcholine, 5-hydroxytryptamine (5-HT) and prostaglandin E2 (PGE2) was studied in-vitro on rat stomach strip. Addition of PAF to the organ bath increased PGE- but not 5-HT- or acetylcholine-evoked responses. The effect of PAF was unaffected by atropine, methysergide or indomethacin, but prevented by a specific PAF receptor antagonist BN 52021. The data support a specific interaction between PAF and PGE2 on rat stomach strip.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/45/8/761/37248919/j.2042-7158.1993.tb07106.x.pdf

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