Flumazenil and lignocaine-induced toxicity: is the inverse agonist type activity circadian-time dependent?-Reference-Cited by-同舟云学术

Flumazenil and lignocaine-induced toxicity: is the inverse agonist type activity circadian-time dependent?

Published:1993-07 Issue:7 Volume:45 Page:678-679
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Bruguerolle Bernard¹,Emperaire Nicolle¹

Affiliation:

1. Medical and Clinical Pharmacology Laboratory, Faculty of Medicine, 27 Bld J. Moulin, F 13385 Marseille Cedex 5, France

Abstract

Abstract We have investigated the possible influence of time of day on the activity of flumazenil on lignocaine-induced toxicity in mice. The circadian pattern of the period of latency for convulsions and the induced mortality for lignocaine alone and for lignocaine plus flumazenil was not statistically significant (cosinor or analysis of variance) but the influence of flumazenil on lignocaine-induced toxicity was circadian-time dependent (F = 27·8, P = 00001).

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/45/7/678/37248905/j.2042-7158.1993.tb05679.x.pdf

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1. Local Anaesthetics;Handbook of Experimental Pharmacology;1997

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