The Release of Sympathetic Amines by Tyramine from the Aortic Walls of Cats

Author:

Lockett Mary F1,Eakins K E1

Affiliation:

1. Department of Physiology and Pharmacology, Chelsea College of Science and Technology, London, S. W.3

Abstract

Abstract Horns of rat uteri in chambers, perfused with the femoral arterial blood of cats, relaxed during pressor responses to intravenous injections of tyramine, but failed to do so when half this weight of tyramine was put directly into the arterial blood bathing the uterine horn. Concentrations of tyramine, evoking only threshold inhibitions of rat uteri, have been shown to release one or more compounds from the isolated perfused aortae of cats. The substances released inhibit the spontaneous and induced contractions of rats' uteri. Finally both adrenaline and noradrenaline have been demonstrated in extracts of cats' aortae.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Cited by 25 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Local modulation of adrenergic neuroeffector interaction in the blood vessel well.;Physiological Reviews;1981-01

2. Release of catecholamine from the cat heart by some directly and indirectly acting sympathomimetic amines;Biochemical Pharmacology;1971-08

3. Influence of lactic acidosis on cardiovascular response to sympathomimetic amines;American Journal of Physiology-Legacy Content;1968-11-01

4. Orientierende Übersicht;Ergebnisse der Physiologie Biologischen Chemie und Experimentellen Pharmakologie;1966-12

5. Kinetics of catecholamine release by tyramine in rat heart, spleen and uterus;Life Sciences;1966-07

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