Affiliation:
1. Research Institute, Brooklyn College of Pharmacy, Long Island University, Brooklyn 16, N.Y
Abstract
Abstract
Glycyrrhetinic acid was found to resemble the Δ4-3-ketosteroids in antagonising uterine growth response to exogenous oestrogen in doses which did not interfere with somatic growth or the oestrogenic effect on pituitary trophic hormones. The anti-oestrogenic effect was not mediated through gonadal inhibition, adrenal stimulation or potentiation of endogenous adrenal corticoids. Glycyrrhetinic acid is neither androgenic, oestrogenic nor anti-androgenic. However, it does resemble the glucocorticoids in depressing granuloma tissue formation in adrenalectomised rats.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Cited by
23 articles.
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