A study of the effects of nabumetone (BRL 14777), a novel anti-inflammatory drug, on cell infiltration into sterile cotton pellets implanted in rats-Reference-Cited by-同舟云学术

A study of the effects of nabumetone (BRL 14777), a novel anti-inflammatory drug, on cell infiltration into sterile cotton pellets implanted in rats

Published:1982-09 Issue:9 Volume:34 Page:580-583
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

FREEMAN P C¹,MANGAN F R¹,WATKINS D K¹

Affiliation:

1. Beecham Pharmaceuticals Research Division, Medicinal Research Centre, The Pinnacles, Harlow, Essex, CM19 5AD, U.K.

Abstract

Abstract Nabumetone a new non-steroidal anti-inflammatory drug is active in reducing the DNA content of implanted cotton pellets in rats on various dosing regimens. The effect of nabumetone can be seen during the early and late phases of the cellular reaction to the implant implicating effects upon polymorphonuclear leucocytes and monocytes. The levels of two lysosomal enzymes are reduced in the exudate by the drug treatment.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/34/9/580/37627197/j.2042-7158.1982.tb04797.x.pdf

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