Effect of nabumetone (BRL 14777), a new anti-inflammatory drug, on human platelet reactivity ex vivo: comparison with naproxen-Reference-Cited by-同舟云学术

Effect of nabumetone (BRL 14777), a new anti-inflammatory drug, on human platelet reactivity ex vivo: comparison with naproxen

Published:1982-09 Issue:9 Volume:34 Page:576-579
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

NUNN BARBARA¹,CHAMBERLAIN P D¹

Affiliation:

1. Beecham Pharmaceuticals Research Division, Biosciences Research Centre, Great Burgh, Yew Tree Bottom Road, Epsom, Surrey, KT18 5XQ, U.K.

Abstract

Abstract The effect of nabumetone (BRL 14777) on human platelet reactivity ex vivo was compared with that of naproxen at equitherapeutic doses in the same six subjects. Nabumetone had only a weak and equivocal effect on collagen-induced and second phase aggregation in response to adenosine diphosphate and adrenaline. After nabumetone, platelets fully aggregated in response to sodium arachidonate, though approximately twice as much was needed as on control occasions. Sodium arachidonate was unable to elicit a full aggregation response after naproxen. These results suggest that nabumetone may cause less interference with haemostasis than other non-steroidal anti-inflammatory drugs.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/34/9/576/37627116/j.2042-7158.1982.tb04796.x.pdf

Reference15 articles.

1. Nabumetone (BRL 14777, 4-[6-methoxy-2-naphthyl]-butan-2-one): a new anti-inflammatory agent

2. The Effects of “Anti-platelet” Drugs on Bleeding Time and Platelet Aggregation in Normal Human Subjects

3. The effect of acetylsalicylic acid and indomethacin on rabbit platelet adherence to collagen and the subendothelium in the presence of a low or high hematocrit

4. Isolation and Structure of Two Prostaglandin Endoperoxides That Cause Platelet Aggregation

Cited by 29 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Assessment of Common Nonsteroidal Anti-Inflammatory Medications by Whole Blood Aggregometry: A Clinical Evaluation for the Perioperative Setting;World Neurosurgery;2014-11

2. Nabumetone;Drugs;2004

3. Platelet function is inhibited by non-selective non-steroidal anti-inflammatory drugs but not by cyclo-oxygenase-2-selective inhibitors in patients with rheumatoid arthritis;Rheumatology;2002-04-01

4. Effect of nabumetone and aspirin on colonic mucosal bleeding time;Alimentary Pharmacology & Therapeutics;2001-04

5. Treatment of Elderly Patients with Nabumetone or Diclofenac;Journal of Clinical Gastroenterology;2001-04