Effects of solvent medium on solubility. A linear free energy relationship treatment

Abstract

Abstract Linear relationships exist between the logarithms of the solubility equilibria of structurally closely related compounds, as they vary with changes in solvent or solvent composition in water and water-like solvents, trie slope Py of these linear free energy relationships quantitatively accounts for the direction and intensity of the relative solubility variations due to medium effects. Results obtained by applying the concept to series of both p-hydroxy- and p-aminobenzoic esters, and α-aminoacids, are presented. These results are explained by a simple model in terms of solute-solvent interactions.