Antibacterial properties of 5-nitro-2-furylglyoxylidene derivatives

Author:

Buckett W R1,Kidd D1

Affiliation:

1. Research Department, Edinburgh Pharmaceutical Industries Limited, Wheatfield Road, Edinburgh, 11

Abstract

Abstract 5-Nitro-2-furylglyoxal has been prepared and nine new derivatives synthesised. These showed similar in vitro antibacterial activity to the corresponding 5-nitro-furfurylidene analogues. The antibacterial activity of the 5-nitro-2-furylglyoxylidenes could not be demonstrated in the serum or urine of rats after oral administration.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

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