Affiliation:
1. Winthrop Laboratories, Newcastle upon Tyne 3
2. Sterling-Winthrop Research Institute, Rensselaer, N.Y
Abstract
Abstract
The even distribution of non-conjugated paracetamol in the tissue waters of the dog has been confirmed. The mean tissue water: plasma water concentration is 1·1. A technique for the determination of non-conjugated paracetamol in man has been devised from existing methods. It has increased sensitivity and is applicable to the routine determination of a large number of samples. This method determines only non-conjugated paracetamol, the sulphated and glucuronated conjugates do not interfere with its accuracy, and it gives results comparable with previous methods. In man, 45 min. after oral administration of paracetamol, the whole blood: plasma concentration ratio is virtually constant at 1·1, indicating that the determination of non-conjugated paracetamol in whole blood should give a satisfactory indication of tissue level.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Cited by
38 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献