A Hypothesis for the Mode of Action of α-Methyldopa in Relieving Hypertension-Reference-Cited by-同舟云学术

A Hypothesis for the Mode of Action of α-Methyldopa in Relieving Hypertension

Published:1963-09 Issue:1 Volume:15 Page:221-224
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Day M D¹,Rand M J¹

Affiliation:

1. Department of Pharmacology, School of Pharmacy, University of London, Brunswick Square, London, W.C.1

Abstract

Abstract There is evidence that α-methyldopa can serve as the precursor of α-methylnoradrenaline in the body. The α-methylnoradrenaline so formed may enter noradrenaline storage sites and then be released as a false neuro-transmitter. Because of the lesser potency of α-methylnoradrenaline there is some loss of responsiveness to sympathetic nerve stimulation which can explain the lowering of blood pressure in hypertensive patients.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/15/1/221/37756100/j.2042-7158.1963.tb12778.x.pdf

Reference19 articles.

1. A STUDY OF THE ADRENOTROPIC RECEPTORS

2. The action of sympathomimetic amines in animals treated with reserpine

3. Effect of Alpha-Methyl DOPA in Severe and Malignant Hypertension

4. In-Vivo Decarboxylation of α-Methyl DOPA and α-Methyl Metatyrosine

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