Effects of chronic nicotine pretreatment on (+)-amphetamine and nicotine-induced synthesis and release of [3H]dopamine from [3H]tyrosine in rat nucleus accumbens-Reference-Cited by-同舟云学术

Effects of chronic nicotine pretreatment on (+)-amphetamine and nicotine-induced synthesis and release of [3H]dopamine from [3H]tyrosine in rat nucleus accumbens

Published:1989-01 Issue:1 Volume:41 Page:66-68
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Fung Yiu K¹

Affiliation:

1. University of Nebraska Medical Center, Department of Oral Biology, College of Dentistry, 40th and Holdrege, Lincoln, NE 68583-0740, USA

Abstract

Abstract The effects of chronic (14 day) administration of nicotine (1·5 mg kg−1 day−1) on the rat nucleus accumbens have been examined. Pretreatment of animals with nicotine increased the endogenous level of dopamine. The ability of (+)-amphetamine to stimulate formation and release of [3H]dopamine from [3H]tyrosine was greatly potentiated in tissue slices from the nucleus accumbens of rats pretreated with nicotine. Furthermore, nicotine was effective in stimulating the formation and release of from [3H]dopamine from [3H]tyrosine in tissue slices from chronic nicotine-treated animals.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/41/1/66/37189648/j.2042-7158.1989.tb06334.x.pdf

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