L-Ascorbic acid produces hypoglycaemia and hyperinsulinaemia in anaesthetized rats-Reference-Cited by-同舟云学术

L-Ascorbic acid produces hypoglycaemia and hyperinsulinaemia in anaesthetized rats

Published:1989-05 Issue:5 Volume:41 Page:345-346
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Cheng J T¹,Hsieh-Chen S C¹,Tsai C L¹

Affiliation:

1. Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan City, Taiwan 70101, Republic of China

Abstract

Abstract L-Ascorbic acid (Vitamin C) produced a marked reduction in the blood glucose concentration following intravenous injection (20–100 mg kg−1) to anaesthetized rats. This hypoglycaemic effect was accompanied by an increase in plasma insulin concentration. D-ascorbic acid produced a similar hypoglycaemic effect.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/41/5/345/37235897/j.2042-7158.1989.tb06471.x.pdf

Reference6 articles.

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3. Vitamin C and diabetes mellitus;Ginter;Nutrition and Health,1983

4. Evidence forguanosine 3′, 5′-monophosphate as a putative mediator of insulin secretion from isolated rat islets;Laycock;Endocrinology,1981

5. The influence of Vitamin C (ascorbic acid) on glucose tolerance, insulin activity and insulin elimination from the blood;Losert;Arzneim Forsch/Drug Res.,1980

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