Affiliation:
1. Department of Pharmacology of the University of Florence, Italy
Abstract
Abstract
Rabbit lung and heart show clorgyline-resistant benzylamine oxidase activity which is sensitive to semicarbazide (SSAO) and α-amino-guanidine. This SSAO activity is inhibited by pyridoxamine with an IC50 of 6·3 × −6 M for lung and of 1·1 × 10−5 M for heart, the inhibition being non-competitive and only partially reversed by dialysis at 4°C. Semicarbazide, α-aminoguanidine and pyridoxamine show a similar time-dependent type of inhibition of rabbit lung and heart SSAO.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Cited by
11 articles.
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