An In-vitro Study of the Interactions Between Intravenous Induction Agents and the Calcium Antagonists Verapamil and Nifedipine-Reference-Cited by-同舟云学术

An In-vitro Study of the Interactions Between Intravenous Induction Agents and the Calcium Antagonists Verapamil and Nifedipine

Published:1989-12 Issue:12 Volume:41 Page:840-843
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Bunting P¹,Ramsay T M¹,Pleuvry B J¹

Affiliation:

1. Departments of Anaesthesia and Physiological Sciences, Stopford Building, University of Manchester, Manchester M13 9PT, UK

Abstract

Abstract Thiopentone, propofol and etomidate inhibit the contractions of the rat isolated atria and portal vein. The actions of thiopentone and propofol summate with those of verapamil and nifedipine. Verapamil potentiates the action of etomidate on both preparations. The depressant actions of thiopentone and propofol on the portal vein are associated with a reduced response to calcium. Etomidate does not reduce the response to calcium in this preparation.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/41/12/840/37199484/j.2042-7158.1989.tb06383.x.pdf

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