Absence of [3H]SCH 23390 binding sites in the rat adrenal gland-Reference-Cited by-同舟云学术

Absence of [3H]SCH 23390 binding sites in the rat adrenal gland

Published:1989-09 Issue:9 Volume:41 Page:646-648
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Zdilar D¹,Lacković Z¹

Affiliation:

1. Laboratory of Molecular Neuropharmacology, Department of Pharmacology, School of Medicine, University of Zagreb, Salata 11, 41000 Zagreb, Yugoslavia

Abstract

Abstract The binding of D2-dopamine receptor ligand [3H]spiperone and selective D1-ligand [3H]SCH 23390 to the rat adrenal gland and striatum has been compared. [3H]Spiperone showed specific binding in both tissues revealing a Bmax of 887 fmol mg−1 protein and KD of 0·38 nM, and B of 34 fmol mg−1 protein and KD of 0·66 nM in the striatum and adrenal gland, respectively. On the other hand, [3H]SCH 23390 showed a specific binding to the striatal tissue with Bmax of 747 fmol mg−1 protein and KD of 0·70 nM, while in the adrenal tissue no specific binding was observed. These results apparently indicated only D2-dopamine receptor binding sites being present in the rat adrenal gland.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/41/9/646/37236144/j.2042-7158.1989.tb06550.x.pdf

Reference20 articles.

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Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Autoradiographic Localization of Dopamine D2-Like Receptors in the Rat Adrenal Gland;Clinical and Experimental Hypertension;1995-01

2. Pharmacological characterization and autoradiographic localization of dopamine receptors in the human adrenal cortex;European Journal of Endocrinology;1994-07