Phenolic analogues of diastereoisomeric 2-methyl reversed esters of pethidine-Reference-Cited by-同舟云学术

Phenolic analogues of diastereoisomeric 2-methyl reversed esters of pethidine

Published:1989-03 Issue:3 Volume:41 Page:209-211
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Casy A F¹,Dewar G H¹,Pascoe R A¹

Affiliation:

1. School of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, BA2 7 AY, UK

Abstract

Abstract The preparation and stereochemical characterization of α- and β-isomers of 1,2-dimethyl-4–m-hydroxyphenyl-4-propiony-loxypiperidine are described. Both the α (axial 4-aryl/chair) and β (equatorial 4-aryl/chair) isomers were of low potency or inactive in mice antinociceptive tests. Shortcomings of the α-isomer as a model for the 4-arylpiperidine moiety of morphine are discussed.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/41/3/209/37195025/j.2042-7158.1989.tb06434.x.pdf

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