Human liver and plasma aspirin esterase-Reference-Cited by-同舟云学术

Human liver and plasma aspirin esterase

Published:1989-06 Issue:6 Volume:41 Page:407-409
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Williams Faith M¹,Mutch E M¹,Nicholson E¹,Wynne H¹,Wright P²,Lambert D²,Rawlins M D¹

Affiliation:

1. Wolfson Unit of Clinical Pharmacology, Newcastle upon Tyne NE1 7RU, UK

2. Department of Surgery, University of Newcastle upon Tyne, Newcastle upon Tyne NE1 7RU, UK

Abstract

Abstract The plasma, in addition to the liver, is a major site of hydrolysis of aspirin. Human plasma and liver aspirin esterase activities in samples from a group of patients varied over a two fold range and there was a significant correlation between individual plasma and liver activities. Human liver aspirin esterase was present in the cytosolic and microsomal fractions. Cytosolic and microsomal enzymes had different activities and apparent affinities for aspirin.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/41/6/407/37235854/j.2042-7158.1989.tb06487.x.pdf

Reference14 articles.

1. Identification and partial purification of the major hydrolysing enzyme in human blood;Costello;Arthr. Rheum.,1983

2. Comparative study of human intestinal and hepatic esterases as related to enzymatic properties and hydrolysing activity for ester type drugs;Inoue;Jap. J. Pharmacol.,1980

3. Studies on aspirin esterase of human serum;Morikawa;Ibid.,1986

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