Affiliation:
1. Phamaceutical Section, Department of Chemical Technology, University of Bombay, Matunga, Bombay, 400 019, India
Abstract
Abstract
The bioavailability of drugs from conventional ophthalmic formulations is low. To optimize the therapy, sustained release ophthalmic dosage forms are warranted. Hydrogels such as sodium-carboxymethyl cellulose, hydroxypropylmethyl cellulose, Carbopol-940, Carbopol-941 and Lutrol-FC-127 increase the duration of action of various drugs. Gels containing pilocarpine were prepared and evaluated by measuring the intensity and duration of miotic response in albino rabbits. Carbopol-940 gels, being the best of those used, were studied further for the effect of its concentration and of additives (benzalkonium chloride, phenylmercuric nitrate, chlorbutol and disodium edetate), autoclaving at 121°C for 30 min and irradiation with gamma rays (2·5 Mrad), on the end product.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Reference18 articles.
1. Ocular controlled-release drug administration;Chien,1982
2. Ocular evaluation of methyl cellulose vehicle in albino rabbits;Chrai;J. Pharm. Sci.,1974
3. Hydrogels based on poly(acrylic acid). Galenical and pharmacodynamic investigations;Giroux;II. Pharm. Acta Helv.,1964
Cited by
38 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献