Affiliation:
1. Department of Pharmacology, Obafemi Awolowo College of Health Sciences, Ogun State University, Sagamu, Nigeria
Abstract
Abstract
Noradrenaline (0·6–19 μM and phenylephrine (2–130 μM induced contractions in the rat seminal vesicle that were competitively antagonized by the α1-adrenoceptor-selective antagonist corynanthine (120–920 nM). Yohimbine (60–450 nM), an α2 adrenoceptor-selective antagonist, produced a non-competitive antagonism of noradrenaline responses, suggesting that the responses were not α2-adrenoceptor mediated. It is concluded that the rat seminal vesicle has a predominance of α1-adrenoceptors.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Cited by
7 articles.
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