Effects of Tapioca Obtained From Cassava (Manihot utilissima) on the Disintegration and Dissolution Rates of Paracetamol Tablets-Reference-Cited by-同舟云学术

Effects of Tapioca Obtained From Cassava (Manihot utilissima) on the Disintegration and Dissolution Rates of Paracetamol Tablets

Published:1989-01 Issue:1 Volume:41 Page:7-10
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Esezobo S¹,Zubair S²,Pilpel N²

Affiliation:

1. Department of Pharmaceutics & Pharmaceutical Technology, Faculty of Pharmacy, University of Benin, Benin City, Nigeria

2. Chelsea Department of Pharmacy, King’s College, University of London, Manresa Road, London SW3 6LX, UK

Abstract

Abstract The properties of tapioca obtained from cassava (Manihot utilissima) have been evaluated. Its binding effect in tablets of paracetamol on the disintegration and dissolution rates was compared with tablets prepared with polyvinylpyrrolidone and gelatin. The nature and amount of the binders were found to alter the disintegration and dissolution rates of the tablets by reducing their wettability as measured by the adhesion tension of water. A linear relationship has been found to exist between the adhesion of water on the tablets and their disintegration and dissolution rates.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/41/1/7/37189711/j.2042-7158.1989.tb06319.x.pdf

Reference17 articles.

1. The effects of interacting variables on the tensile strength, disintegration and dissolution of oxytetra-cycline-lactose tablets;Adeyemi;Int. J. Pharm.,1984

2. Measuring rates of liquid penetration into tablets;Alkan;Pharm. Technol.,1982

3. Some formulation factors affecting the tensile strength, disintegration and dissolution of uncoated oxytetracycline tablets;Esezobo;J. Pharm. Pharmacol.,1976

4. Formulation factors affecting strength and dissolution of uncoated oxytetracycline tablets;Esezobo;J. Pharm. Sci.,1977

5. The wetting of powders of acetylsalicylic acid, salicylic acid, phenacetin and paracetamol;Fell;J. Pharm. Pharmacol.,1978

Cited by 4 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Effect of polymer ratio on the quality of a co-processed excipient of prosopis gum and crab shell chitosan;Tropical Journal of Pharmaceutical Research;2018-10-03

2. Compressional, mechanical and release properties of a novel gum in paracetamol tablet formulations;Current Issues in Pharmacy and Medical Sciences;2014-09-01

3. Evaluation of starches obtained from four Dioscorea species as binding agent in chloroquine phosphate tablet formulations;Saudi Pharmaceutical Journal;2011-04

4. Non-ionic surfactant vesicles (niosomes): Physical and pharmaceutical chemistry;Advances in Colloid and Interface Science;1995-06