Affiliation:
1. Pharmaceutical Department, ICI Ltd., Pharmaceuticals Division, Macclesfield, Cheshire, England
Abstract
Abstract
A chromatographic method for the determination of oxytetracycline is described, employing a hexane-ethyl acetate-pH 3·3 buffer partition system supported on Celite. Chromatographic separation is followed by measuring the absorbance of the eluate at 263 nm. The system enables the determination of oxytetracycline to be made in the presence of anhydro-oxytetracycline, chlortetracycline, α- and β-apo-oxytetracycline, and epi-oxytetracycline, the last three being the most likely contaminants of crude material.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Cited by
5 articles.
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