Gas chromatographic identification of thioridazine in plasma, and a method for routine assay of the drug-Reference-Cited by-同舟云学术

Gas chromatographic identification of thioridazine in plasma, and a method for routine assay of the drug

Published:1969-10 Issue:10 Volume:21 Page:674-677
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Curry S H¹,Mould G P¹

Affiliation:

1. Department of Pharmacology and Therapeutics, London Hospital Medical College, Turner Street, London, E. 1, England

Abstract

Abstract Thioridazine had a retention time of approximately 4 min on a 3% OV-17 gas chromatographic column at 260°. Using flame or argon ionization detectors samples as low as 0μ01 μg could be detected. The drug could be extracted into n-heptane containing 1·5% isoamyl alcohol or 20% toluene. Recovery of drug added to plasma was 100%. Unchanged thioridazine was identified in the plasma of two experimental samples, on the basis of chromatographic and solvent distribution data.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/21/10/674/37712972/j.2042-7158.1969.tb08144.x.pdf

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