Affiliation:
1. Research Department, Roche Products Ltd., Welwyn Garden City, Herts., England
Abstract
Abstract
Picrotoxin, leptazol, nikethamide and bemegride were found to antagonize the bronchoconstrictor effects of acetyl-β-methylcholine in the guinea-pig anaesthetized with urethane. The analeptics were also active in pithed animals but not in animals that had been adrenalectomized or pretreated with propranolol. Catecholamine release from the adrenals can account for the effects observed.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Cited by
7 articles.
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