The evaluation of inflammation induced by material implanted subcutaneously in the rat

Abstract

Abstract Inflammation induced by cotton pellets, implanted subcutaneously in the rat, has been compared with that resulting from implantation of pellets impregnated with irritant substances. Time sequences of fluid exudation and granulation tissue formation have been evaluated by differential weighing. Increased irritancy of the pellets resulted in increased exudate volume, and heavier granulation deposition. Contact between granulation tissue and irritant pellets was delayed until the volume of exudate had subsided. Penetration of the pellet was also delayed. Systemic anti-inflammatory effects from granulomata surrounding implanted pellets were related to either the size of the implantation lesion or the degree of irritancy of the implanted material. Evaluation of granulation tissue formation is suggested as a test for irritancy of surgical fabrics.