Role of fetuin-A in atherosclerosis associated with diabetic patients-Reference-Cited by-同舟云学术

Role of fetuin-A in atherosclerosis associated with diabetic patients

Published:2012-07-04 Issue:12 Volume:64 Page:1703-1708
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Singh Monika¹,Sharma Pramod Kumar¹,Garg Vipin Kumar¹,Mondal Shambhu Charan¹,Singh Avnesh Kumar¹,Kumar Nikhlesh²

Affiliation:

1. Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology, Meerut, India

2. Department of Pharmaceutical Technology, Divya Jyoti College of Pharmacy, Modinagar, Uttar Pradesh, India

Abstract

Abstract Objectives Fetuin-A is a circulating glycoprotein, formed in the liver. It regulates bone remodelling and calcium metabolism. Fetuin-A has adipogenic properties, so fat accumulation in the liver may be associated with higher levels of fetuin-A. Fetuin-A is an inhibitor of the phosphorylation of the insulin receptor tyrosine kinase. Key findings High concentrations of fetuin-A in humans causes insulin resistance. Insulin sensitivity is also found to be increased in fetuin-A knockout mice. Fetuin-A has been shown to cause insulin resistivity in type-2 diabetes mellitus and worsens the pro-atherogenic milieu. Summary Fetuin-A should be considered as a hepatic bio-marker. Vascular diseases like atherosclerosis are major causes of disability in patients with diabetes mellitus.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/64/12/1703/36384446/j.2042-7158.2012.01561.x.pdf

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