The Purity of Chloroform B.P

Abstract

Abstract The “chloro-compound”, isolated during previous work on a source of error in the assay of strychnine salts and preparations1, has been identified as strychnine chloromethobromide. Its identity has been established by the preparation of authentic strychnine chloromethobromide and the corresponding nitrate and iodide. Chlorobromomethane occurs in chloroform B.P. used for extraction of strychnine during the assay. The presence of this impurity in chloroform has been confirmed by gas chromatography which also revealed the presence of methylene dichloride as an additional impurity.