Antitussive and Other Pharmacological Properties of the Diethylaminoethoxyethyl Ester of αα-Diethylphenylacetic Acid, (OXELADIN)

Abstract

Abstract The diethylaminoethoxyethyl ester of αα-diethylphenylacetic acid (oxeladin) appears to possess similar antitussive activity to carbetapentane and to be slightly less active than codeine phosphate. Sensory nerve endings in the trachea and bronchial tree are not the site of action. The acute toxicity is not significantly different from that of carbetapentane. The ester is two to four times as toxic as codeine phosphate, according to species and route of administration. It has local anaesthetic properties, being approximately twice as active as procaine hydrochloride by the guinea pig intracutaneous wheal test. Only excessive amounts appear to have a constipating effect in normal mice. A spasmolytic effect has been demonstrated with the isolated guinea pig ileum and isolated rabbit duodenum. It has, however, a spasmogenic effect on the jejunum of the anaesthetised cat. Intravenous injection in the anaesthetised cat produced a transient fall in blood pressure of the same magnitude as that produced by codeine phosphate. It has been administered to rats over a prolonged period with no untoward effect on the growth rate and the haemopoietic system.