Desipramine and nortriptyline antagonize apomorphine and reserpine hypothermia by a different mechanism

Abstract

Abstract The reversal of hypothermia, induced by reserpine or by a high (16 mg) dose of apomorphine, in male Swiss mice, does not seem to utilize a common mechanism. Desipramine (20 mg kg−1 i.p., 60 min) or nortriptyline (8 mg kg−1 i.p., 60 min) increased temperature in both reserpine (2.5 mg kg−1 s.c, 18–19 h) and apomorphine (16 mg kg−1 s.c, 30 min) treated mice. In apomorphine-treated animals the effect of both drugs was reversed by the mixed dopaminergic D1- D2-antagonist haloperidol (1 mg kg− i.p 90 min), the D1-receptor blocking drug SCH 23390 (0.05 mg kg−1 s.c, 30 min), the ?1-adrenoceptor blocking drugs prazosin (3 mg kgsp>−1 s.c., 90 min) and phenoxybenzamine (20 mg kg−1 i.p., 65 min), the ?-adrenoceptor blocking drug (±)-propranolol (10 mg kg−1 i.p., 120 min), and the opioid antagonist naloxone (2 mg kg−1 i.p., 15 min). In contrast the selective D2-antagonist (±)-sulpiride (100 mg kg−1 i.p., 90 min), and the ?2-antagonist yohimbine (2 mg kg−1 i.p., 75 min), failed to effect the reversal of apomorphine hypothermia brought about by desipramine or nortriptyline. Their temperature effects in reserpinized mice were not modified by any of the antagonists tested.